Immune Protection against H9N2 Provided by H1N1 Pre-infection in Pigs.
- Author:
Jia WANG
;
Maocai WU
;
Wenshan HONG
;
Zuoyi ZHENG
;
Rirong CHEN
- Publication Type:Journal Article
- MeSH:
Animals;
Antibodies, Viral;
immunology;
Cross Reactions;
Immune Sera;
immunology;
Influenza A Virus, H1N1 Subtype;
immunology;
physiology;
Influenza A Virus, H9N2 Subtype;
immunology;
Orthomyxoviridae Infections;
blood;
immunology;
Species Specificity;
Swine;
immunology;
virology
- From:
Chinese Journal of Virology
2015;31(4):357-362
- CountryChina
- Language:Chinese
-
Abstract:
To explore the impact of the history of infection by the influenza A virus subtype H1N1 on secondary infection by the influenza A virus subtype H9N2, pigs non-infected and pre-infected with H1N1 were inoculated with H9N2 in parallel to compare nasal shedding and seroconversion patterns. Unlike pigs without a background of H1N1 infection, nasal shedding was not detected in pigs pre-infected with H1N1. Both groups generated antibodies against H9N2. However, levels of H1N1 antibodies in pigs pre-infected with H1N1 increased quickly and dramatically after challenge with H9N2. Cross-reaction was not observed between H1N1 antibodies and H9N2 viruses. These findings suggest that circulation of the H1N1 virus might be a barrier to the introduction and transmission of the avian H9N2 virus, thereby delaying its adaptation in pigs.
