Progress in Research on Structure, Function and Antiviral of Enterovirus A71 3C Protein.
- Author:
Jing LI
;
Hongling WEN
;
Zhiyu WANG
- Publication Type:Journal Article
- MeSH:
Animals;
Antiviral Agents;
pharmacology;
Enterovirus;
drug effects;
immunology;
metabolism;
physiology;
Humans;
Immunity, Innate;
Viral Proteins;
chemistry;
genetics;
metabolism;
Virus Replication;
drug effects
- From:
Chinese Journal of Virology
2015;31(4):468-473
- CountryChina
- Language:Chinese
-
Abstract:
Enterovirus A71 (EV-A71) causes hand, foot, and mouth disease (HFMD) and various neurological complications, including aseptic meningitis and neurogenic pulmonary edema in young children. HFMD caused by EV-A71 have broken out several times in the Asia-Pacific region since 2007. And it has been a serious threat to public health. There is no effective vaccine or antiviral drug. The pathogenesis of EV-A71 infection is unknown, and EV-A71 3C protein plays an irreplaceable role in replication and anti - innate immunity. Further research on EV-A71 3C protein is conducive to understand the pathogenesis of EV-A71 infection and antiviral drug.
