Research Progress in the Function of SUMOylation during Infection by the Influenza Virus.
- Author:
Huimin LIU
;
Wenqing LI
;
Lijuan SU
;
Guozhi ZHANG
;
Yan LI
;
Xiao LI
;
Hongtao CHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Influenza, Human;
virology;
Orthomyxoviridae;
genetics;
metabolism;
Sumoylation;
Viral Proteins;
genetics;
metabolism;
Virus Replication
- From:
Chinese Journal of Virology
2015;31(5):560-564
- CountryChina
- Language:Chinese
-
Abstract:
The influenza virus has evolved numerous mechanisms to overcome host defenses for its benefit. It can also manipulate the immune system to stop it monitoring and clearing the virus. Small ubiquitin-like modifier (SUMO)ylation is emerging as a key post-translational modification that plays an important part in virus replication. This brief review focuses on recent findings on the roles of SUMOylation during infection by the influenza virus. As such, it will aid understanding of the mechanism of action of infection by the influenza virus, and help to provide new strategies for anti-viral treatment.
