Research Progress in the Core Proteins of the Classical Swine Fever Virus.
- Author:
Yuzhen HOU
;
Dantong ZHAO
;
Guoying LIU
;
Fan HE
;
Bin LIU
;
Shaoyin FU
;
Yongqing HAO
;
Wenguang ZHANG
- Publication Type:Journal Article
- MeSH:
Animals;
Classical Swine Fever;
virology;
Classical swine fever virus;
genetics;
metabolism;
pathogenicity;
Genome, Viral;
Swine;
Viral Core Proteins;
chemistry;
genetics;
metabolism;
Virulence
- From:
Chinese Journal of Virology
2015;31(5):579-584
- CountryChina
- Language:Chinese
-
Abstract:
The core protein (CP) of the classical swine fever virus (CSFV) is one of its structural proteins. Apart from forming the nucleocapsid to protect internal viral genomic RNA, this protein is involved in transcriptional regulation. Also, during viral infection, the CP is involved in interactions with many host proteins. In this review, we combine study of this protein with its disorders, structural/functional characteristics, as well as its interactions with the non-structural proteins NS3, NS5B and host proteins such as SUMO-1, UBC9, OS9 and IQGAP1. We also summarize the important part played by the CP in CSFV pathogenicity, virulence and replication of genomic RNA. We also provide guidelines for further studies in the CP of the CSFV.
