Analysis of HA and NA Genes of Influenza A H1N1 Virus in Yunnan Province during 2009-2014.
- Author:
Juan LI
;
Xiaonan ZHAO
;
Yihui CAO
;
Deming NING
;
Xiaoqing FU
;
Wen XU
- Publication Type:Journal Article
- MeSH:
China;
epidemiology;
Hemagglutinin Glycoproteins, Influenza Virus;
genetics;
metabolism;
Humans;
Influenza A Virus, H1N1 Subtype;
classification;
enzymology;
genetics;
isolation & purification;
Influenza, Human;
epidemiology;
virology;
Molecular Sequence Data;
Mutation;
Neuraminidase;
genetics;
metabolism;
Phylogeny;
Viral Proteins;
genetics;
metabolism
- From:
Chinese Journal of Virology
2015;31(6):674-678
- CountryChina
- Language:Chinese
-
Abstract:
To analyze influenza pathogen spectrum in Yunnan province during 2009-2014 years, and analyze HA and NA genes of influenza A H1N1. Analysis was made on the monitoring date of influenza cases in Yunnan province in recent 6 years, 23 strains of influenza virus of HA and NA gene was sequenced and analyzed by MEGA 5 software to construct phylogenetic tree. 4 times of influenza AH1N1 epidemic peak were monitored from 2009-2014 years in Yunnan Province, as the nucleic acid detection results of influenza A H1N1 accounted for 28.8% of the total. The sequencing result showed that HA and NA gene were divided into 3 groups, one was detected with H275Y mutation strains. Influenza A H1N1 is one of the important subtypes in Yunnan province and their genes have divided into three branches during the period of 2009-2014 years, the vast majority of influenza a H1N1 are still sensitive to neuraminidase inhibitors.
