Advances in Parvovirus Non-structural Protein NS1 Induced Apoptosis.
- Author:
Mengyu TU
;
Fei LIU
;
Shun CHEN
;
Mingshu WANG
;
Anchun CHENG
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Humans;
Parvoviridae Infections;
physiopathology;
veterinary;
virology;
Parvovirus;
genetics;
metabolism;
Viral Nonstructural Proteins;
genetics;
metabolism
- From:
Chinese Journal of Virology
2015;31(6):679-684
- CountryChina
- Language:Chinese
-
Abstract:
Until now, more than seventeen parvovirus have been reported which can infect mammals and poultries. The infected cells appeared different properties of apoptosis and death, present a typical cytopathic effect. NS1 is a major nonstructural protein of parvovirus, with a conservative structure and function, which plays an important role in the viral life cycle. In addition to the influence on viral replication, the NS1 also participates in apoptosis induced by viruses. Parvovirus induced apoptosis which is mainly mediated by mitochondrial pathway, this review summarized the latest research progresses of parvovirus induced apoptosis.
