Progress on the Function of Herpesvirus-encoded MicroRNAs.
- Author:
Zhenzhen CAI
;
Renyong JIA
- Publication Type:Journal Article
- MeSH:
Animals;
Herpesviridae;
genetics;
metabolism;
Herpesviridae Infections;
virology;
Humans;
MicroRNAs;
genetics;
metabolism;
RNA, Viral;
genetics;
metabolism
- From:
Chinese Journal of Virology
2015;31(6):704-711
- CountryChina
- Language:Chinese
-
Abstract:
Since Epstein Barr virus was shown to encode microRNAs(miRNAs) in 2004, more than 470 miRNAs have been discovered in α-, β-, and γ-herpesviruses. MiRNAs are small non-coding RNA molecules and generally only have 18-25 nucleotides in length, which can regulate the expression of target genes by targeting its transcripts. Herpesvirus-encoded miRNAs not only target the key genes from latency to lytic replication, but also regulate various host cellular genes. Current data manifest that herpesvirus-encoded miRNAs can regulate viral latent infection and lytic replication, immune recognition, apoptosis, and tumorigenesis. The purpose of this paper is to summarize the targets and their fuction of hepesvirus-encoded miRNAs, in order to provide theoretical support for further analysis herpesviral pathogenesis.
