Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension.
- Author:
Shan-Fa YU
1
;
Wen-Hui ZHOU
;
Kai-You JIANG
;
Gui-Zheng GU
;
Sheng WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; China; epidemiology; Employment; psychology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Hypertension; epidemiology; genetics; Male; Polymorphism, Genetic; Power Plants; Prevalence; Receptors, Adrenergic, beta-2; genetics; Stress, Psychological; complications; Young Adult
- From: Biomedical and Environmental Sciences 2008;21(3):239-246
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension.
METHODSA cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP.
RESULTSJob stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05).
CONCLUSIONHigh job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.
