Molecular epidemiological study on prevalence of human papillomaviruses in patients with common warts in Beijing area.
- Author:
Yan-Jun LEI
1
;
Chen GAO
;
Chen WANG
;
Jun HAN
;
Jian-Ming CHEN
;
Guang-Cai XIANG
;
Qi SHI
;
Hui-Ying JIANG
;
Wei ZHOU
;
Run AN
;
Chen-Fang DONG
;
Yu-Kang YUAN
;
Xiao-Ping DONG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; China; epidemiology; DNA, Viral; Female; Genetic Variation; Humans; Male; Middle Aged; Papillomaviridae; classification; genetics; isolation & purification; Phylogeny; Prevalence; Warts; epidemiology; virology
- From: Biomedical and Environmental Sciences 2009;22(1):55-61
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the circulation, distribution, and genomic diversity of HPVs in common warts in Beijing area of China.
METHODSForty eight patients with pathologically diagnosed common warts were screened for the presence of HPV with HPV type-specific PCR and direct sequencing analysis. The genomic diversity of HPVs prevalent in Chinese patients was analyzed based on LCR.
RESULTSForty one (85.5%) samples were positive for HPV DNA, 13 (31.7%)--HPV-57, 12 (29.3%)--HPV-1a, 7 (17%)--HPV-27 and 5(12.2%)--HPV-2a. Four cases were infected with two different HPV types, two (4.9%) with HPV-1a and HPV-27, one (2.4%) with HPV-1 and HPV-57 and one (2.4%) with HPV-27 and HPV-57. In contrast to the prevalence of single strain of novel HPV-57 variant and HPV-1 prototype, two HPV-2 and three HPV-27 novel variants were found to circulate in Beijing.
CONCLUSIONHPV-1, -2, -27 and -57 are predominantly prevalent in patients with common warts in Beijing.
