Estimating the effectiveness of nimodipin in treatment of children with intracranial hemorrhage
- Author:
Huong Thi Thanh Nguyen
;
Ung Thi Ninh
;
Thong Minh Pham
;
Huyen Thi Thanh Ho
- Publication Type:Journal Article
- Keywords:
Intracranial hemorrhage;
Nimodipin
- MeSH:
Intracranial Hemorrhages/ therapy;
Nimodipine/ therapeutic use;
Infant
- From:Journal of Medical Research
2007;55(6):58-64
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Background:Cerebral vasospasm is a proved reaction and nimodipin revolutionised the treatment of subarrachnoid hemorrhage in adult. However, the effectiveness of Nimodipin in cerebral vasospasm remained controversial in intracranial hemorrhage (lCH) in children. Objectives:This study aims to estimate the effectiveness of nimodipin in treatment of children with intracranial hemorrhage.Subjects and method:A descriptive, prospective study was conducted on all children patients diagnosed intracranial hemorrhage and treated at Neurology department of National Hospital for Pediatric, Vietnam from 2004 to June 2007. They applied the Transcranial Doppler sonography (TCD) in diagnosis of vasospasm in intracranial hemorrhage in children and follow-up the evolution after treatment with nimodipin. Results:The results showed that cerebral vasospasm with hight resistance index (RI) on TCD (RI = 0.78 \xb1 0.08) and cerebral ischemie with low systolic velocity (Vs = 68 \xb1 12.2 crn/s) and hight pulsality index (PI = 1.4 \xb1 0.13) were observed in 100% of cases after 3 days with ICH. Nimodipine improved clinical status (71.2%) and CT scan (52%), also RI, PI, Vs returned to normal when used nimodipin within 7 days of ICH. Conclusion: The treatment method for intracranial hemorrhage with nimodipin supplement had proved to have initial effecacy in comparison with traditional method.
