Association between high sensitivity C-reactive protein levels in serum and the 5-year-accumulative-risk of diabetes
10.3760/cma.j.issn.0254-6450.2011.01.001
- VernacularTitle:血清高敏C反应蛋白水平与五年累积糖尿病发病风险的关系
- Author:
Hai-Hang LIU
1
;
Dong ZHAO
;
Wei WANG
;
Lan-Ping QIN
;
Jun LIU
;
Jia-Yi SUN
;
Miao WANG
;
Yan LI
;
Yue QI
;
Jing LIU
Author Information
1. 首都医科大学附属北京安贞医院
- Keywords:
Diabetes;
High-sensitivity C-reactive protein;
Prospective study
- From:
Chinese Journal of Epidemiology
2011;32(1):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the association between hs-CRP(high-sensitivity C-reactive protein) levels in serum and the 5-year-accumulative-risk of diabetes in a general population.Methods Participants were from the cohort of Peking University residential community in the Chinese Multi- provincial Cohort Study(CMCS). Two surveys on cardiovascular risk factors and the measurements of serum hs-CRP levels were conducted in 2002 and 2007, respectively. Individuals with incomplete information and those having infectious diseases at baseline were excluded. A total of 1045 participants aged 45 to 74 years and free of diabetes at baseline were included in this analysis.Results The age-standardized 5-year accumulative incidence rate of diabetes was 8.8% (male:9.8%, female: 8.2% ) and increased significantly with the level of hs-CRP in both women and men (P＜0.01). After adjustment for age, hypertension, low-density liproprotein cholesterol, and high-density liproprotein cholesterol, triglycerides, fasting glucose, smoking status and central obesity,people with hs-CRP≥3 mg/L had a 3.30 times higher risk of developing diabetes in men and 2.58 times for women when compared to those with hs-CRP＜1 mg/L. The areas under the receiver operating characteristic curves of baseline hs-CRP level in predicting the incidence of diabetes were 0.619(95%CI:0.536-0.701 ) in men and 0.667(95%CI:0.585-0.749) in women. Conclusion Serum hs-CRP levels could predict the incidence of diabetes, indicating that inflammation might have great importance in the onset of diabetes.
