Association between apolipoprotein A5 gene polymorphism and coronary heart disease in the Han population from Xinjiang
10.3760/cma.j.issn.0254-6450.2011.01.013
- VernacularTitle:载脂蛋白A5 c.553G＞T基因多态性与新疆汉族人群冠心病相关性研究
- Author:
Shan YUAN
1
;
Yi-Tong MA
;
Xiang XIE
;
Yi-Ning YANG
;
Zhen-Yan FU
;
Xiang MA
;
Xiao-Mei LI
;
Fen LIU
;
Bang-Dang CHEN
Author Information
1. 新疆医科大学
- Keywords:
Coronary heart disease;
Apolipoprotein A5;
Serum lipids;
Gene polymorphism
- From:
Chinese Journal of Epidemiology
2011;32(1):51-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective The aim is to investigate the association between coronary heart disease (CHD) and c.553G＞T polymorphism of apolipoprotein A5 (ApoA5) gene and the influence of serum lipid level in the Hah ethnic population of Xinjiang. Methods The polymorphism of ApoA5 gene in 486 patients with CHD and 501 controls was analyzed by methods of polymerase chain reaction and restriction fragment length polymorphism analysis. Level of serum lipid in each patient was detected at the same time. Results There was significant difference in the distribution of genotypes between CHD group and controls group ( x2 = 8.757, P= 0.013 ). Non-conditioned logistic regression analyses, after adjusted for age, gender, smoking, total serum cholesterol, presence of hypertension and diabetes, revealed that individuals who carried T allele (TT + GT genotype) had an increased risk of CHD, compared to GG genotype (OR= 1.753,95%CI: 1.030-2.983, P＜0.05 ). There was also a remarkable difference noticed in the level of serum triglyceride by genotypes in CHD group and control group (t=5.242, P＜0.01; t=-3.499, P=0.001 ). Individuals in the two groups who carried T allele had higher level of serum triglyceride than those carried GG genotype. Individuals in CHD group who carried T allele had higher level of serum total cholesterol than those carried GG genotype (t=-2.465, P=0.014). Conclusion It seemed that the c.553G＞T polymorphism of ApoA5 gene had influenced on the level of serum triglyceride and the total cholesterol among Han population in Xinjiang. c.553G＞T polymorphism was associated with the development of CHD, while T allele might be an influencing risk factor on CHD.
