Strategies for targeting the DNA damage response for cancer therapeutics.
10.5732/cjc.012.10087
- Author:
Dan ZHANG
;
Hai-Bo WANG
;
Kathryn L BRINKMAN
;
Su-Xia HAN
;
Bo XU
- Publication Type:Editorial
- MeSH:
Antineoplastic Agents;
therapeutic use;
Cell Death;
DNA Damage;
genetics;
DNA Repair;
genetics;
Dose-Response Relationship, Radiation;
Drug Resistance, Neoplasm;
Genomic Instability;
Humans;
Neoplasms;
drug therapy;
genetics;
pathology;
radiotherapy;
Poly(ADP-ribose) Polymerase Inhibitors;
Poly(ADP-ribose) Polymerases;
pharmacology;
Radiation Dosage
- From:Chinese Journal of Cancer
2012;31(8):359-363
- CountryChina
- Language:English
-
Abstract:
The DNA damage response is critical for cells to maintain genome stability and survival. In this review, we discuss approaches to targeting critical elements of the DNA damage response for radiosensitization and chemosensitization. In addition, we also discuss strategies for targeting DNA damage response and DNA repair defects in cancer cells for synthetic lethality.
