A Study of AgNORs(Argyrophilic Nucleolar Organizer Regions) on Prediction of the Prognosis in Intracranial Meningiomas.
- Author:
Ho Sang PARK
1
;
Shin JUNG
;
Sam Suk KANG
Author Information
1. Department of neurosurgery, Chonnam University Hospital & Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Meningioma;
Nucleolar organizer regions;
Cell proliferation
- MeSH:
Cell Proliferation;
Kinetics;
Meningioma*;
Nucleolus Organizer Region*;
Paraffin;
Prognosis*;
Recurrence;
Silver Staining
- From:Journal of Korean Neurosurgical Society
1995;24(6):617-622
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A silver staining technique was used in the study of nucleolar organizer regions(AgNORs) from the paraffin sections of 26 meningiomas. The specimens were divided into four groups as follows:benign(n=16), atypical(n=5), anaplastic or malignant(n=5) and recurrent without atypical histological findings(n=2) groups, and the mean number of AgNORs in each group was 1.47+/-0.27, 1.93+/-0.4, 2.00+/-0.27 and 1.49+/-0.53 respectively. We noted that the mean number of AgNORs reflected the cellular kinetics of a tumor and was related to histological grade. There was no significant difference between non-recurrent & recurrent benign meningiomas and it was thought that the main cause of recurrence in benign meningiomas was not perhaps cell proliferation but incomplete surgical removal.
