The absence of the ERBB4 hotspot mutations in melanomas in patients from southern China.
- Author:
Qi-Ming ZHOU
1
;
Wei LI
;
Yuan-Xiang GUAN
;
Xing ZHANG
;
Xin-Chun CHEN
;
Ya DING
;
Xi-Zhi WEN
;
Rui-Qing PENG
;
Shu-Mei YAN
;
Xiao-Shi ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Asian Continental Ancestry Group; genetics; DNA, Neoplasm; genetics; Extremities; Female; Humans; Male; Melanoma; genetics; metabolism; Middle Aged; Mucous Membrane; Mutation; Paraffin Embedding; Receptor, Epidermal Growth Factor; genetics; metabolism; Receptor, ErbB-4; Skin Neoplasms; genetics; metabolism; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
- From:Chinese Journal of Cancer 2013;32(7):410-414
- CountryChina
- Language:English
- Abstract: V-erb-a erythroblastic leukemia viral oncogene homolog 4 (ERBB4) has been reported to be somatically mutated in 19% of melanoma cases. To investigate the prevalence of ERBB4 mutations in melanoma patients from southern China, we analyzed 117 formalin-fixed, paraffin-embedded melanoma samples archived in the Sun Yat-sen University Cancer Center. A matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) platform was used to screen for mutations. No ERBB4 hotspot mutations were detected. Our results indicate that ERBB4 mutations may play a limited role in melanomas in China; therefore, targeting the ERBB4 mutation in melanoma patients from southern China may not be a promising strategy.
