Study on Contractile Responses Induced by Anoxia in Porcine Cerebral Artery.
- Author:
Jun Seog KO
1
;
Sam Suk KANG
;
Yung Hong BAIK
Author Information
1. Department of Neurosurgery, Chonnam University Hospital & Medical School, Kwangju, Korea.
- Publication Type:Original Article
- Keywords:
Anoxia;
Porcine cerebral arteries;
Endothelium;
Endothelium;
Cyclic GMP;
Prostaglandin
- MeSH:
Anoxia*;
Arteries;
Cerebral Arteries*;
Circle of Willis;
Cyclic GMP;
Dinoprost;
Endothelium;
Indomethacin;
Nimodipine;
Relaxation;
Vasoconstriction
- From:Journal of Korean Neurosurgical Society
1995;24(6):623-630
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This study was designed to observe anoxia-induced responses and to clarify their possible mechanisms in porcine basilar and circle of Willis arteries. Anoxia produced a transient vasoconstriction, which then recovered to the basal tension of a 3-5 min. later, and the reoxygenation that follows produced the biphasic(relaxation-contraction) response in the intact endothelial rings under resting tension. The anoxia-induced contraction was potentiated by pretreatment with KC1 and PGF2alpha. Reoxygenation produced only sustained relaxation. Removal of the endothelium and pretreatment with nimodipine or indomethacine markedly attenuated the anoxia-induced contractions. Anoxia transiently and significantly increased cyclic GMP contents in the endothelium-intact preparations, but did not affect them in the endothelium-removed ones. The above results suggest that anoxia-induced contraction is endothelium-dependent and is resultant to the release of a Prostaglandin-like substance(s) .
