A study on DNA damage of mouse livers induced by methylmercury.
- Author:
Xiaomei LIU
1
;
Zhiwei SUN
;
Long SHI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cell Survival; drug effects; Cells, Cultured; DNA Damage; Hepatocytes; cytology; drug effects; Liver; cytology; drug effects; Male; Methylmercury Compounds; adverse effects; Mice
- From: Chinese Journal of Preventive Medicine 2002;36(1):5-7
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the DNA damage induced by methylmercury (MeHg) in mouse hepatocytes.
METHODSThe single cell gel electrophoresis (SCGE) was used to study the DNA damage of mouse hepatocytes when treated with different doses in vivo and in vitro.
RESULTSAfter treated with high, middle and low doses of MeHg for 12 h in vivo (i.p.), the proportion of DNA damage was increased and the ratio of living cells was decreased; and both effects showed significantly dose-effect relationships. Similar effects were found when different MeHg doses were administered to hepatocytes in vitro for 1 h.
CONCLUSIONMeHg induces DNA damage in mouse hepatocytes.
