A 1:2 matched case-control study on congenital external malformation during perinatal period.

Taishun WU; Songlin LI; Shupei Chen; Likang WU; Jinhui Xiao; Shaofa Nie; Wei Chen; Guibao Zhu

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A 1:2 matched case-control study on congenital external malformation during perinatal period.

Author: Taishun WU ¹ ; Songlin LI ; Shupei CHEN ; Likang WU ; Jinhui XIAO ; Shaofa NIE ; Wei CHEN ; Guibao ZHU
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1. Department of Science and Teaching, The Hygiene and Anti-epidemic Station of Baoan District, Shenzhen City, Shenzhen 518101, China.
Publication Type:Journal Article
MeSH: Case-Control Studies; Congenital Abnormalities; etiology; Female; Humans; Male; Multivariate Analysis; Perinatal Care; Pregnancy; Risk Factors
From: Chinese Journal of Preventive Medicine 2002;36(1):19-21
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the risk factors for congenital external malformation.
METHODSA 1:2 matched case-control study was conducted with 52 cases of congenital external malformation during perinantal period collected from surveillance in Baoan District of Shenzhen City from January to June in 2000.
RESULTSSimple and multiple conditional logistic regression analysis showed that the major risk factors for congenital external malformations during perinatal period were preterm labor (beta(k) = 1.4171, s(theta, beta(kappa)) = 0.4601, OR = 4.115), adverse mental stimulus (beta(kappa) = 2.1870, s(theta beta(kappa)) = 0.7873, OR = 8.909), taking medicine (beta(k) = 1.9178, s(theta beta(kappa)) = 0.8072, OR = 6.808) and exposure to hazardous chemicals during early pregnancy (beta(k) = 0.9602, s(theta beta(kappa)) = 0.4262, OR = 2.612).
CONCLUSIONSCongenital external malformation during perinatal period was caused by multiple risk factors and results of the study showed that environmental and mental factors were in obvious connection with its occurrence.