A study on the relationship between genetic and environmental factors of type 2 diabetes mellitus in humans.
- Author:
Yu CHEN
1
;
Ling ZHOU
;
Yaochu XU
;
Hongbing SHEN
;
Juying NIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Case-Control Studies; China; Diabetes Mellitus, Type 2; epidemiology; etiology; genetics; Environment; Female; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Obesity; Risk Factors
- From: Chinese Journal of Preventive Medicine 2002;36(3):191-194
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo study the relationship between the inheritable factor and environmental factors of type 2 diabetes mellitus in humans.
METHODSA case-control study based on 154 type 2 diabetes mellitus and 130 healthy controls was carried out in Jiangsu Province in 1997.
RESULTSThe age, family history of diabetes mellitus, hypertension history, high waist/hip ratio (WHR), high systolic blood pressure, huge fetus history, and the genotype of beta(3)-adrenergic receptor (beta(3)-AR) were the risk factors of type 2 diabetes mellitus; while occupational physical activity was protective factor of type 2 diabetes mellitus. The risk for diabetes mellitus distinctly increased while genetic factor and obesity, beta(3)-AR mutation were coexisting.
CONCLUSIONType 2 diabetes mellitus is caused by the effect of both genetic and environmental factors.
