Study on the postive frequency and distribution of glutamic acid decarboxylase antibody in phenotypic type 2 diabetec patients.
- Author:
Xia LI
1
;
Zhi-guang ZHOU
;
Gan HAUNG
;
Jian PENG
;
Xiang YAN
;
Lin YANG
;
Jian-ping WANG
;
Zhi-ming DENG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Antibodies; immunology; metabolism; Body Mass Index; Case-Control Studies; Child; Child, Preschool; Diabetes Mellitus, Type 2; diagnosis; metabolism; pathology; physiopathology; Female; Glutamate Decarboxylase; immunology; Humans; Infant; Male; Middle Aged; Phenotype; Young Adult
- From: Chinese Journal of Epidemiology 2005;26(10):800-803
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the positive frequency and distribution of glutamic acid decarboxylase antibody(GAD-Ab) in phenotypic type 2 diabetic(T2DM) patients.
METHODSSera of 2035 phenotypic T2DM patients were screened for GAD-Ab with radioligand assay. The positive frequency of GAD-Ab and its relation with clinical features were analyzed.
RESULTS(1) The positivity of GAD-Ab in clinic-based, phenotypic T2DM patients was 7.1% (145/2035), comparable to that of data from Caucasians as shown by UKPDS(8.7% vs. 9.8%, P = 0.391) and ADOPT (8.0% vs. 4.2%, P = 0.000) but higher than that of Japanese in Ehime study(7.1% vs. 3.8%, P = 0.000). (2) The positive frequency and distribution of GAD-Ab titer were related to clinical features, including age at onset, body mass index (BMI) and fasting C peptide levels. Patients with younger age at onset (0.33 vs. 0.11, P < 0.05), less BMI (0.34 vs. 0.10, P < 0.05) and lower C peptide levels (0.38 vs. 0.11, P < 0.05) would have higher GAD-Ab titers.
CONCLUSION(1)The positivity of GAD-Ab in adult-onset phenotypic T2DM in Chinese was similar to that of Caucasians but higher than that of the Japanese. (2) The distribution of GAD-Ab titers was associated with clinical features, with high GAD-Ab titers for those having younger age at onset, less BMI and lower C peptide levels.