Study on the associations between inflammatory factor and insulin resistance as well as type 2 diabetes with macrovascular complications.
- Author:
Qiao-ying YOU
1
;
Cheng-jiang LI
;
Hong LI
;
Qi-qian ZHU
;
Xu-wei SI
Author Information
- Publication Type:Journal Article
- MeSH: C-Reactive Protein; metabolism; Case-Control Studies; Diabetes Complications; blood; metabolism; pathology; Diabetes Mellitus, Type 2; complications; metabolism; physiopathology; Female; Homeostasis; Homocysteine; blood; Humans; Inflammation Mediators; metabolism; Insulin Resistance; Linear Models; Male; Middle Aged
- From: Chinese Journal of Epidemiology 2005;26(10):804-807
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the possible association between C-reactive (CRP) and insulin resistance (IR) as well as the pathogenesis of type 2 diabetes macrovascular complication.
METHODSSerum CRP was measured by ultrasensitive immuoturbidimetric, which was determined on type 2 diabetes (T2DM) with or without macrovascular complication (70 and 60 cases respectively) and on normal controls (90 cases). IR was estimated by homeostasis model assessment (HOMA-IR).
RESULTSResults showed that the concentration of CRP was higher in T2DM with or without macrovascular complications than that in the healthy subjects (P < 0.01), while it was higher in diabetic patients with macrovascular complications than that in diabetic patients without macrovascular complications (P < 0.01). In diabetic patients with macrovascular complications, person correlation analysis indicated that there existed positive correlations between CRP and FINS, HOMA-IR, triglyceride (TG) while stepwise linear regression showed that usCRP and HOMA-IR, TG having linear correlation.
CONCLUSIONCRP seemed to play a role in the initiation and progression of atherosclerosis in type 2 diabetes, possibly was by the way of IR.
