Glutathione S-transferase M1 polymorphism and the risk on colorectal cancer: a multilevel meta regression.
- Author:
Han-Qing HE
1
;
Kun CHEN
;
Yang ZHANG
;
Feng TONG
;
Chun-Hong FAN
;
Liang SONG
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Colorectal Neoplasms; enzymology; ethnology; genetics; European Continental Ancestry Group; genetics; Genetic Predisposition to Disease; ethnology; Glutathione Transferase; deficiency; genetics; Humans; Multilevel Analysis; Odds Ratio; Polymorphism, Genetic; Regression Analysis; Risk Factors
- From: Chinese Journal of Epidemiology 2005;26(12):992-994
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEIn order to investigate the relationship between Glutathione S-transferase M1 (GSTM1) status and the risk on colorectal cancer as well as to detect the related factors to this association.
METHODSA pooled analysis of multilevel Meta-regression was performed to estimate GSTM1 deficiency associated with the risks of colorectal cancer. Then subgroup Meta-regression was undertaken to evaluate the possible relationship between heterogeneity and the related characteristics.
RESULTSThe overall pooled odds ratios of colorectal cancer risk associated with GSTM1 deficiency was 1.17 (95% CI: 1.08-1.26). Ethnicity, percent of GSTM1 deficiency in population had significant relationships with heterogeneity across the studies (P < 0.05). Results of subgroup Meta-regression showed that GSTM1 deficiency was significantly associated with colorectal cancer risk in ethnic subgroups of Asians, Caucasians and in low level (lower than 50%) of GSTM1 deficiency population (P < 0.05). The respective pooled ORs were 1.14, 1.25 and 1.29.
CONCLUSIONGSTM1 deficiency seemed to be a risk factor for colorectal cancer, while interactions on the characteristics of ethnicity, percentage of GSTM1 deficiency in the studied population were related to this association.
