Study on matrix metalloproteinase 1, 9, 12 polymorphisms and susceptibility to chronic obstructive pulmonary disease among Han nationality in northern China.
- Author:
Rong-bao ZHANG
1
;
Quan-ying HE
;
Rui-hong YANG
;
Bing-bing LU
;
Yu-jing LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Case-Control Studies; China; ethnology; Ethnic Groups; genetics; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Logistic Models; Male; Matrix Metalloproteinase 1; genetics; Matrix Metalloproteinase 12; genetics; Matrix Metalloproteinase 9; genetics; Polymorphism, Genetic; Pulmonary Disease, Chronic Obstructive; genetics
- From: Chinese Journal of Epidemiology 2005;26(11):907-910
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the association between the functional polymorphism of matrix metalloproteinases (MMPs) and the development of chronic obstructive pulmonary disease (COPD).
METHODS147 COPD patients and 120 healthy smoking controls were selected. Spirometry and chest X-rays had been taken. Questionnaires including sex, age, smoking history, occupational exposure were completed. MMP-9 (-1562 C/T), MMP-1(-1607 1G/2G), MMP-12 (-82 A/G), MMP-12(-357 Asn/ Ser) alleles were determined using PCR-RFLP method. Independent samples T test analysis was carried out to compare patients' age, smoking index, FEV1 /FVC, FEV1 % pred with that of healthy controlled group. The frequencies of genotypes and alleles between groups were analyzed by chi-square tests and multilogistic regression.
RESULTSMMP12 Asn/Asn, CT/AsnAsn were risk factors for smoking-induced COPD. The ORs were 2.361 (95% CI: 1.369-4.017) and 2.433(95% CI: 1.159-5.342) respectively while CC/1G1G/ SerSer seemed to be a protective factor for smoking-induced COPD, with OR as 0.457 and 95% CI as 0.231-0.911.
CONCLUSIONAsn/Asn, CT/AsnAsn might be susceptible genotypes while CC/GG/SerSer might serve as protective genotype.
