Introduction on "case-sibling control design".
- Author:
Hong-gang YI
1
;
Feng CHEN
;
Hao YU
;
Yang ZHAO
;
Dong-hua LOU
Author Information
- Publication Type:Journal Article
- MeSH: Case-Control Studies; Chi-Square Distribution; Coronary Disease; genetics; Epidemiologic Methods; Gene Frequency; Genetic Association Studies; Genetic Linkage; Humans; Methylenetetrahydrofolate Reductase (NADPH2); genetics; Polymorphism, Genetic; Research Design; Siblings
- From: Chinese Journal of Epidemiology 2006;27(2):170-173
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo introduce the design and statistical methods of case-sibling control design and to analyze the published data.
METHODSData from an association study between the coronary heart disease and methylenetetrahydrofolate reductase gene C677T polymorphism was analyzed by the sib transmission/disequibrium test (s-TDT) and the sibship disequilibrium (SDT) methods.
RESULTSUsing s-TDT method, Z value was 0.27 with P > 0.05. The result of SDT method showed that chi-square was 0.31 with 1 df, P > 0.05. All results suggested that neither s-TDT nor SDT showed significant difference between the transmitted and untransmitted methylenetetrahydrofolate reductase gene C677T allele distributions.
CONCLUSIONCase-sibling control design might avoid population stratification by using siblings as controls thus might be used to test association and linkage between genes and disease.
