Association of ABCG2 gene C421A polymorphism and susceptibility of primary gout in Han Chinese males.
- VernacularTitle:ABCG2基因第5外显子C421A多态与中国汉族男性原发性痛风的相关性研究
- Author:
Fa-gui LI
1
;
Yi CHU
;
Dong-mei MENG
;
Ya-wen TONG
Author Information
- Publication Type:Journal Article
- MeSH: ATP Binding Cassette Transporter, Sub-Family G, Member 2; ATP-Binding Cassette Transporters; genetics; Adult; Aged; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Gene Frequency; Genetic Predisposition to Disease; Gout; genetics; Humans; Male; Middle Aged; Neoplasm Proteins; genetics; Polymorphism, Single Nucleotide
- From: Chinese Journal of Medical Genetics 2011;28(6):683-685
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between a C421A single nucleotide polymorphism (SNP) in exon 5 of ATP-binding cassette, sub-family G (WHITE), member 2 (ABCG2) gene and susceptibility of primary gout in Han Chinese males.
METHODSFor 200 male patients with primary gout and 235 controls, the genotype of C421A locus was analyzed by PCR and direct sequencing. Blood glucose, uric acid, total cholesterol, triglycerides, creatinine and urea nitrogen was measured by an automatic biochemical analyzer.
RESULTSCompared with the controls, there was a higher frequency for AA genotype and A allele of the rs2231142 SNP in gout patients (22.5% vs. 8.5% by genotype; 44.9% vs. 32.3% by allele). The association with gout reached significance (chi-square =15.91, P< 0.001, crude OR=3.02, 95% CI:1.36-4.90 and OR (adjusted by age)=1.80, 95% CI: 1.32-2.45 by dominant mode; chi-square=6.82, P=0.009, OR=1.67, 95% CI: 1.54-2.27 by recessive mode). Blood glucose, uric acid, triglycerides, creatinine and urea nitrogen levels in gout patients were significantly higher than those of controls (P< 0.001).
CONCLUSIONThe C421A SNP, in particular AA phenotype, may be associated with susceptibility of primary gout in Han Chinese males.
