A new human leukocyte antigen class I allele, HLA- B*52:11.
- VernacularTitle:HLA-Ⅰ类基因新等位基因HLA-B*52:11的序列分析及确认
- Author:
Xiao-feng LI
1
;
Xu ZHANG
;
Kun-lian ZHANG
;
Yang CHEN
;
Xian-zhi LIU
;
Jian-ping LI
Author Information
- Publication Type:Case Reports
- MeSH: Alleles; Amino Acid Sequence; Base Sequence; Genotype; HLA-B Antigens; genetics; Humans; Molecular Sequence Data; Sequence Alignment; Sequence Analysis, DNA
- From: Chinese Journal of Medical Genetics 2011;28(6):712-715
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify and confirm a novel HLA allele.
METHODSA new human leukocyte antigen class I allele was found during routine HLA genotyping by polymerase chain reaction-sequence specific oligonucleotide probes (PCR-SSOP) and sequencing-based typing (SBT).
RESULTSThe novel HLA-B*52 allele was identical to B*52:01:01 with an exception of one base substitution at position 583 of exon 3 where a C was changed to T resulting in codon 195 changed from CAC(H) to TAC(Y).
CONCLUSIONA new HLA class I allele, B*52:11, is identified, and is named officially by the WHO Nomenclature Committee.
