Genetic polymorphisms of six Y chromosome short tandem repeat loci in Chinese Korean ethnic group.
- VernacularTitle:中国朝鲜族六个Y染色体短串联重复基因座遗传多态性的研究
- Author:
Yong-ji ZHANG
1
;
Song-hua LI
;
Hong-rui DUAN
Author Information
- Publication Type:Journal Article
- MeSH: Alleles; China; Chromosomes, Human, Y; Ethnic Groups; genetics; Gene Frequency; Humans; Korea; ethnology; Male; Polymorphism, Genetic; Tandem Repeat Sequences
- From: Chinese Journal of Medical Genetics 2012;29(1):82-86
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo determine the allelic sequences and genetic polymorphism of six short tandem repeats (STRs) loci on Y chromosome, including DYS441, DYS442, DYS443, DYS444, DYS445 and DYS446 in Chinese Korean ethnic males from Yanbian region of Jilin province, China, and to construct a preliminary database.
METHODSAllele frequencies of the six STR loci in 205 Chinese Korean ethnic individuals were analyzed by multiplex polymerase chain reaction (PCR) and polyacrylamide gel electrophoresis (PAGE).
RESULTSRespectively, 8, 7, 7, 5, 6 and 9 alleles were detected for each of the locus. Together they have formed 151 haplotypes, with a diversity of 0.9937.
CONCLUSIONThe six STR loci included in this study were found to be highly polymorphic, and may provide useful markers for genetic analysis.
