Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia.
- Author:
Meng-meng SUN
1
;
Lan-fen LIU
;
Li-min YANG
;
Yan WANG
;
Kai-yan CUI
;
Li-na WANG
;
Cui-luan LI
;
Dong-dong QIAO
;
Ru-zhan WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Brain-Derived Neurotrophic Factor; genetics; China; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Schizophrenia; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2012;29(2):155-158
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.
METHODSGenotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).
RESULTSA significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.
CONCLUSIONBDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.
