A versatile role of transcription regulator CTCF in epigenetics and diseases.
10.3760/cma.j.issn.1003-9406.2012.02.013
- Author:
Qiu-ying LIU
1
;
Yang QIN
Author Information
1. Department of Biochemistry and Molecular Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, People's Republic of China.
- Publication Type:Journal Article
- MeSH:
CCCTC-Binding Factor;
Disease;
genetics;
Epigenomics;
methods;
Humans;
Repressor Proteins;
genetics;
Transcription Factors;
genetics;
Zinc Fingers;
genetics
- From:
Chinese Journal of Medical Genetics
2012;29(2):176-180
- CountryChina
- Language:Chinese
-
Abstract:
CTCF as a multivalent eukaryotic transcription factor plays a diverse range of roles in regulation of various genes through the binding of its 11 zinc fingers to CTCF consensus sites or various proteins. CTCF is involved in multiple aspects of epigenetic regulation including regulation of chromatin remodeling and genomic imprinting. Deregulation of these processes result in a group of diseases are characterized by growth, development, and neurological dysfunction. This paper reviews recent researches that highlight the links between CTCF, epigenetics and diseases.
