Association between plasma lipid, glucose, cortisol and adrenocorticotropic hormone levels and GR and ACTHR gene polymorphisms.
- VernacularTitle:GR和ACTHR基因多态性与血脂、血糖、皮质醇以及促肾上腺皮质激素水平的相关性
- Author:
Yu-long LIAN
1
;
Xian WEI
;
Qian WANG
;
Li NING
;
Chen ZHANG
;
Ji-wen LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adrenocorticotropic Hormone; blood; genetics; Adult; Blood Glucose; genetics; metabolism; Female; Genotype; Humans; Hydrocortisone; blood; genetics; Lipids; blood; genetics; Male; Middle Aged; Polymorphism, Genetic; Receptors, Glucocorticoid; genetics
- From: Chinese Journal of Medical Genetics 2012;29(2):188-193
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the association between plasma fat and glucose, cortisol and adrenocorticotropic hormone (ACTH) levels and genotypes of GR and ACTHR genes in healthy Chinese Han subjects.
METHODSTwo hundred healthy subjects were analyzed for GR and ACTHR gene polymorphisms using PCR-restriction fragment length polymorphism method. Plasma lipid, glucose, cortisol, ACTH levels were determined and correlated with the genotypes.
RESULTSNo significant difference was found between plasma lipid and glucose levels and various GR and ACTHR genotypes. Subjects with AG genotype of GR 5556A/G polymorphism had lower plasma cortisol levels than AA genotype. Compared with subjects with GG genotype of GR 4534-4536GAG/AAA [GAGAGG (GluArg)>GAAAAG(GluLys)] polymorphism, those with AG genotype had significantly lower plasma cortisol levels. Subjects with CC and CG genotypes of GR 6294C/G polymorphism also had significantly lower plasma cortisol levels compared with those with GG genotype. With regard to plasma ACTH levels, those with TT genotype of ACTHR 2T/C polymorphism were significantly lower than CC and CT genotypes, and those with AG genotype for GR 5556 A/G polymorphism were also significantly lower than AA genotype.
CONCLUSIONThere was no difference in plasma cortisol and glucose levels between subjects with GR and ACTHR gene variants. GR gene variants (5556A/G, 4534-4536GAG/AAA and 6294C/G polymorphisms) may influence plasma cortisol level, and ACTHR 2T/C, GR 5556A/G polymorphisms may decrease plasma ACTH level.