Association between rs6658835 polymorphism of transforming growth factor beta 2 gene and congenital heart diseases in Chinese Han population.
- Author:
Jun XIE
1
;
Yu CHEN
;
Hui LI
;
Bin ZHOU
;
Li RAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Asian Continental Ancestry Group; genetics; Child; Female; Genetic Predisposition to Disease; Heart Defects, Congenital; genetics; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide; Transforming Growth Factor beta2; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2012;29(2):210-213
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between a tag single nucleotide polymorphism (rs6658835) of transforming growth factor beta 2 (TGF beta2) gene and congenital heart disease (CHD) in Chinese Han population.
METHODSA total of 324 CHD cases including 144 atrial septal defects (ASD), 88 patent ductus arteriosus (PDA), 92 ventricular septal defects (VSD) and 158 healthy controls were enrolled. The genotype of rs6658835 was determined by polymerase chain reaction-restriction fragment length polymorphism assay.
RESULTSThe genotypic and allelic frequencies of rs6658835 were associated with VSD (P< 0.05), but not with ASD or PDA (P> 0.05).
CONCLUSIONThe rs6658835 polymorphism of TGF beta 2 gene is associated with the susceptibility of VSD in Chinese Han population.
