Genome-wide association study with memory measures as a quantitative trait locus for schizophrenia.
- VernacularTitle:精神分裂症记忆功能的全基因组关联分析
- Author:
Bo XIANG
1
;
Jun-yao WU
;
Xiao-hong MA
;
Ying-cheng WANG
;
Wei DENG
;
Zhuang-fei CHEN
;
Ming-li LI
;
Qiang WANG
;
Zong-ling HE
;
Li-jun JIANG
;
Tao LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Female; Genetic Predisposition to Disease; Genome-Wide Association Study; methods; Humans; Male; Memory; physiology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Schizophrenia; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2012;29(3):255-259
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association between gene polymorphisms and memory function through a genome-wide association study (GWAS) of schizophrenia and control group. Memory cognition was used as a quantitative trait (QT).
METHODSNinty-eight subjects with chronic schizophrenia and 60 matched controls were genotyped with HumanHap660 Bead Array. The results were correlated with quantitative traits including memory and memory delay.
RESULTSFive candidate genes, including RASGRF2 (rs401758, P = 8.03×10(-5)), PLCG2 (rs7185362, P= 4.54×10(-5)), LMO1 (rs484161, P=9.80×10(-7), CSMD1 (rs2469383, P= 2.77×10(-6)) and PRKG1 (rs7898516, P=6.94×10(-5)) were associated with memory cognition deficits.
CONCLUSIONUsing memory cognition as a quantitative trait, this Genome- wide association study has identified 5 susceptibility loci. With their association with nervous system development, neuronal growth, axon guidance and plasticity, brain development, above loci may play a role in the development of memory dysfunction in schizophrenia.
