Optimization of matrix formulation of effective parts cataplasm of Pogostemon cablin by uniform design.
- Author:
Xiao-Gen WANG
1
;
Yu-Fan ZOU
;
Yu-Zhen CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adhesiveness; Biocompatible Materials; chemistry; Chemistry, Pharmaceutical; Drugs, Chinese Herbal; chemistry; metabolism; Lamiaceae; chemistry; metabolism; Regression Analysis; Skin Absorption; Volatilization
- From: China Journal of Chinese Materia Medica 2008;33(6):638-641
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo optimize the matrix formulation of the effective part Cataplasm of Pogostemon Cablin.
METHODThe optimal preparation prescription was selected by U17 (17(11)) uniform design,and the tacking strength, cohesive strength and transdermal speed constant were used as test indexes. The equations of three test indexes were established by SPSS. With analysis of the contribution of factors by SPSS regression, the optimal matrix formulation was acquired.
RESULTThe optimal matrix formulation is carbopol U10-NoveriteTM7s-glycerine-sorbitol-kaolin-citric acid-aluminum trichloride (1.0:5.0:20:2.0:2.0:0.25:0.2).
CONCLUSIONThe matrix has good adhesive property, proper drug release rate, desirable hemocompatibility with the extractions of Pogostemon cablin.
