Studies on chemical constituents of Sarcandra glabra.
- Author:
Xu-Dong XU
1
;
Xiao-Ru HU
;
Jing-Quan YUAN
;
Jun-Shan YANG
Author Information
- Publication Type:Journal Article
- MeSH: Anti-Bacterial Agents; analysis; chemistry; isolation & purification; pharmacology; Coumarins; analysis; isolation & purification; pharmacology; Drugs, Chinese Herbal; chemistry; Magnetic Resonance Spectroscopy; Magnoliopsida; chemistry; Porphyromonas gingivalis; drug effects; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Streptococcus mutans; drug effects
- From: China Journal of Chinese Materia Medica 2008;33(8):900-902
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study antibacterial chemical constituents of Sarcandra glabra.
METHODThe constituents of the chloroform and EtOAc-soluble portions of the EtOH extract from the whole plant of S. glabra, which posses the antibacterial activities, were isolated and purified with column chromatography. The compounds were identified by physical and spectroscopic techniques.
RESULTSix compounds were isolated and identified as 4, 4'-biisofraxidin (1), esculetin (2), fraxetin (3), scoparone (4), isofraxidin (5), scopoletin(6), respectively.
CONCLUSIONCompound 1 is a novel natural product. Compounds 24 were isolated from the plants of Chloranthaceae for the first time. The antibacterial activities of these six compounds were tested for the first time. Some compounds may have potential for future study and development as plant-derived oral antibacterial agents.
