Experimental study of saikosaponin-D (SSd) on lipid peroxidation of hepatic fibrosis on rat.
- Author:
Yan HE
1
;
Zhi-Feng HU
;
Ping LI
;
Cheng XIAO
;
Yu-Wu CHEN
;
Ke-Ming LI
;
Jing-Zhen GUO
;
Lin PAN
;
Jia-Peng XIONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aspartate Aminotransferases; blood; Collagen Type IV; blood; Dimethylnitrosamine; adverse effects; Hyaluronic Acid; blood; Laminin; blood; Lipid Peroxidation; drug effects; Liver Cirrhosis; blood; chemically induced; drug therapy; metabolism; Malondialdehyde; blood; Oleanolic Acid; analogs & derivatives; pharmacology; therapeutic use; Rats; Saponins; pharmacology; therapeutic use; Superoxide Dismutase; blood
- From: China Journal of Chinese Materia Medica 2008;33(8):915-919
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of SSd on lipid peroxidation during experimental hepatic fibrosis progression.
METHODThe experimental models of hepatic fibrosis were induced by intraperitoneal injection of dimethylnitrosamine (DMN) on rats. SSd was administered by intraperitoneal injection for 4 weeks. Serum was analyzed for alanine and aspartate aminotransferase (ALT and AST), hyaluronic acid (HA), laminin (LN), collagen IV (IV-C), malonaldehyde (MDA) and superoxide dismutase (SOD) activities. Liver samples were measured for MDA contents and SOD activities in normal group, model group and SSd group.
RESULTSSd significantly decreased ALT and AST activities and lowered HA, LN and IV-C contents. It enhanced SOD activities in liver, while reduced MDA contents both in serum and liver.
CONCLUSIONSSd has obvious effects of protecting hepatocytes and resisting hepatic fibrosis, and the mechanism may be associated with its anti-lipid peroxidation effect.
