Hepatic and renal injury induced by Radix Aristolochiae or Guanxin Suhe Wan for a long-term in rats.
- Author:
Hong-Xiang QIAO
1
;
Yong-Ye LIU
;
Li-Mao WU
;
Lian-Da LI
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Aristolochia; chemistry; toxicity; Drugs, Chinese Herbal; toxicity; Kidney; drug effects; metabolism; pathology; Liver; drug effects; metabolism; pathology; Male; Rats; Rats, Sprague-Dawley; Stomach Neoplasms; chemically induced; Urinary Bladder; drug effects; metabolism; pathology; Urinary Bladder Neoplasms; chemically induced
- From: China Journal of Chinese Materia Medica 2008;33(9):1044-1048
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the toxicity of Radix Aristolochiae supplied experimental evidence of rational use of drug in clinic.
METHODAfter treatment with small dose Radix Aristolochiae, Guanxin Suhe Wan (with Radix Aristolochiae) and Guanxin Suhe Wan (without Radix Aristolochiae) in different group for a long- term, respectively, the biochemical indicator of PT, ALT, AST, ALB, ALP, Crea and BUN were detected, and the kidney, liver, stomach and urinary bladder were examined by pathologic assaying.
RESULTIn Radix Aristolochiae group and Guanxin Suhe Wan (with Radix Aristolochiae) group, all of biochemical indicator were changed significantly, and hepatonecrosis, renal tubular necrosis, gastric carcinoma and bladder carcinoma were discovered.
CONCLUSIONRadix Aristolochiae and Guanxin Suhe Wan (with Radix Aristolochiae) can damage kidney and liver, and cause gastric carcinoma and bladder carcinoma by intensive toxicity.
