Sdudy on effect of tripterygium on plasma IL-18 content in patients with lupus nephritis.
- Author:
Cai-Yun JIN
1
;
Guo-Hua HU
;
Bi-Zhong ZHENG
;
Dong-Lian WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Drugs, Chinese Herbal; adverse effects; therapeutic use; Female; Humans; Interleukin-18; blood; Lupus Nephritis; blood; drug therapy; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Tripterygium; chemistry; Young Adult
- From: China Journal of Chinese Materia Medica 2008;33(9):1075-1077
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVEIt is to study the effect of tripterygium (TW) on the plasma IL-18 content in patients with lupus nephritis (LN) and its treatment value.
METHODThe patients with LN treated with prednisone were divided into active groupand inactive group with active index. The active group was given tripterygium additionally. The changing of plasma IL-18 and release of nephritis were observed after treatment for three months.
RESULTThe level of plasma IL-18 lowered down obviously, urinary protein decreased, LN activity index, hematuria and renal function improved.
CONCLUSIONTripterygium caninhibitroduction of plasma IL-18. It has definite treatment value on controlling LN activity.
