Effect of several penetration enharcers on transdermal permeation and skin accumulation of artemether.
- Author:
Jun-Yao HE
1
;
Shi-Xiang HOU
;
Zheng CAI
;
Dan-Dan GUO
;
Rong-Li ZHAO
Author Information
- Publication Type:Journal Article
- MeSH: Adjuvants, Pharmaceutic; chemistry; Animals; Artemisinins; administration & dosage; pharmacokinetics; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; In Vitro Techniques; Male; Permeability; drug effects; Rats; Rats, Wistar; Skin; drug effects; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(10):1130-1132
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate penetration characteristics of artemether and the effect of different permeation enhancer on transdermal permeation of artemether through rat skin.
METHODThe permeation experiments were performed using rat skin on modified Franz diffusion cells in vitro. The concentrations of artemether in receptor compartment at specified time points were determined by HPLC.
RESULTThe permeating ratio through human skin of artemether solution was Js (2.78 +/- 0.78) microg x cm(-2) x h(-1), the quantity of drug penetrated through and accumulated in the skin by the end of the experiment were (69.07 +/- 3.01) microg x cm(-2), (58.93 +/- 3.56) microg x cm(-2) respectively. Four different permeation enhancers can improve the transdermal permeation of artemether.
CONCLUSIONArtemether have the potential to be developed to new transdermal preparation.
