Influence of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in diabetes rats induced by streptozocin.
- Author:
Ming-San MIAO
1
;
Gui-Lan ZHANG
;
Yan-Yan MIAO
;
Jing-Jing SHI
;
Hui-Li LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Blood Glucose; drug effects; Diabetes Mellitus; drug therapy; Diabetes Mellitus, Experimental; drug therapy; Humans; Kidney; drug effects; ultrastructure; Male; Pancreas; drug effects; ultrastructure; Plant Extracts; administration & dosage; Rats; Rats, Wistar; Saponins; administration & dosage; Streptozocin; Zea mays; chemistry
- From: China Journal of Chinese Materia Medica 2008;33(10):1179-1183
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo discuss the effect of Zea mays L. saponin (ZMLS) on ultrastructure of kidney and pancreas in the diabetes rats induced by streptozocin.
METHODThe diabetic rat model was established by injections of STZ, blood glucose, the ultrastructure of the kidney and pancreas were observed.
RESULTCompared with the model group, the large, middle-dose ZMLS groups and melbinum group could remarkably decrease the blood glucose (P < 0.01), the large, middle, small-dose ZMLS groups could remarkably prevent the pancreatic islet beta-cell from the injury induced by Streptozotocin. Melbinum and the large, middle-dose ZMLS groups could remarkably increase mitochondrial Vv, deltam and euchromatin Vv (P < 0.01), and significantly decrease the delta, Nucleus delta and heterochromatin Vv (P < 0.01). The small dose of ZMLS obviously increases mitochondrial Vv (P < 0.05).
CONCLUSIONZMLS showed good effect on decreasing blood glucose and protection action on the kidney and pancreas injury of induced by STZ.
