Comparision study pharmacokinetics of different source cinnamon acid.
- Author:
Wen-Lan LI
1
;
Xiao-Dong WHANG
;
Yu-Bin JI
;
Zheng-Ting HU
;
Xiao-Lei REN
;
Jia WHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cinnamomum zeylanicum; chemistry; Drugs, Chinese Herbal; administration & dosage; pharmacokinetics; Male; Rabbits; Serum; chemistry; drug effects
- From: China Journal of Chinese Materia Medica 2008;33(10):1192-1195
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study relatively pharmacological activities of cinnamon acid in blood serum of rabbit administered cinnamon acid, cinnamon and Jingui Shenqi pills.
METHODRP-HPLC determine and analysis blood serum sample from rabbits administered cinnamon acid, cinnamon and Jingui Shenqi pills. Condition of colour spectrum was Symmetry C18 (3.9 mm x 150 mm, 5 microm) chromato bar, mobile phase was methanol-1% glacial acetic acid water-solution (45:55), flow rate was 0.8 mL x min(-1), temperature of bar was 35 degrees C, detection wave length was 285 nm. The serum pharmacokinetic parameters were calculated with 3p87.
RESULTLinear range of cinnamon acid is from 0.06-15 microg x mL(-1) (r = 0.9997), the lowest detectability is 0.054 microg x mL(-1). Pharmacokinetic process of cinnamon acid in rabbit could be all fitted to two-compartment model.
CONCLUSIONSensitive and exclusive HPLC that adopt can exactly detect serum concentration in rabbits administerd cinnamon acid. Pharmacokinetic parameters of three conditions can reveal pharmacokinetics regularity of cinnamon acid in rabbit.
