Preparation and quality evaluation of intravenous tanshinone II (A) emulsion.
- Author:
Zhen LIANG
1
;
Sheng-Jun MAO
;
Zong-Ning YIN
;
Hui JIN
;
Hui LI
;
Ting CHU
Author Information
- Publication Type:Journal Article
- MeSH: Centrifugation; Diterpenes, Abietane; Drug Stability; Drug Storage; Emulsions; Hydrogen-Ion Concentration; Injections, Intravenous; Particle Size; Phenanthrenes; administration & dosage; chemistry; Quality Control; Temperature
- From: China Journal of Chinese Materia Medica 2008;33(11):1249-1252
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo prepare and evaluate an intravenous emulsion of tanshinone II(A).
METHODSoybean phospholipid mixing with poloxamer 188 was used as emulsifier. Oleic acid and glycerol were used as co-emulsifier and isoosmotic adjusting agent, respectively. The coarse emulsion was first prepared and following homogenization was carried out for the coarse emulsion by using a high pressure homogenizer.
RESULTThe average diameter of the prepared tanshinone II (A) emulsion was 211 nm with a zeta potential of -32. 1 mV. There had no changes of diameter, zeta potential, pH value, content and physical appearance for the tanshinone II (A) emulsion stored at 25 degrees C away from light during one year.
CONCLUSIONThe physicochemical properties of the prepared tanshinone II (A) emulsion was stable, which could meet the requirements of intravenous administration.
