Influence of different penetration enhancers on Lappaconitine transcutaneous permeation.
- Author:
Min HAN
1
;
Yun-Wei ZHONG
;
Xin-Ping LI
;
Zheng WU
;
Wen-Quan LIANG
;
Jian-Qing GAO
Author Information
- Publication Type:Journal Article
- MeSH: Aconitine; analogs & derivatives; metabolism; Chromatography, High Pressure Liquid; Drugs, Chinese Herbal; metabolism; Humans; Permeability; drug effects; Skin; cytology; metabolism
- From: China Journal of Chinese Materia Medica 2008;33(11):1252-1255
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of different kinds and concentration of transdermal enhancers on Lappaconitine transcutaneous permeation when used individually or together.
METHODUsing modified Franz-type diffusion cell and excised human body skin as an in vitro transdermal model, the concentration of lappaconitine was determined by HPLC, then cumulative permeation quantity (Q) and stability rate (J) of progesterone were calculated.
RESULTPenetration enhancers such as propylene glycol, dodecanol, IPM, and particularly 3% OA and Azone, can significantly enhance the penetration rate of lappaconitine. Concentration effect of penetration enhancers concentration on lappaconitine transcutaneous permeation were found in experiments, the permeation effect of Azone was better than Azone + OA and Azone + propylene glycol.
CONCLUSIONThe transdermal rate of lappaconitine from batch which contains 3% OA or Azone is higher than others. Combination of Azone with other penetration enhancers is not recommended for Lappaconitine transcutaneous permeation.
