Association between endothelial nitric oxide synthase gene (G894T) polymorphism and essential hypertension in Uygur populations.
- Author:
Li-ping ZHANG
1
;
Shi-zhen WANG
;
Xue-xin ZHAO
;
Bo LIAN
;
Xiao-feng WANG
;
Ren-yong LIN
;
Da-ru LU
;
Li JIN
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Case-Control Studies; China; epidemiology; Exons; Female; Gene Frequency; Genotype; Humans; Hypertension; epidemiology; ethnology; genetics; Male; Middle Aged; Nitric Oxide Synthase Type III; genetics; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide
- From: Chinese Journal of Cardiology 2006;34(5):403-406
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association between G894T polymorphism and essential hypertension (EH) in Uygur population in Xinjiang province.
METHODSIn this case-control study, G894T genotypes in 375 hypertension patients (EH group) and 414 normotensive control subjects (NT group) from the rural area of Tuluafan of Xinjiang was investigated by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method.
RESULTS(1) Significant differences were found in GG, GT and TT frequencies of G894T genotypes between the EH and NT groups (56.5%, 28.3%, 15.2% in EH group and 65.9%, 22.5%, 11.6% in NT group, OR = 2.97, 95% CI 1.393 - 6.358). T allele frequencies were significantly higher in EH group (29.33%) than that in NT group (22.83%, P < 0.05). (2) SBP, DBP in patients with T allele of eNOS gene [(171.36 +/- 22.30) mm Hg and (103.63 +/- 13.22) mm Hg] were significantly higher than that of GG genotype [(158.07 +/- 20.850) mm Hg and (89.90 +/- 10.39) mm Hg] (P < 0.01).
CONCLUSIONSeNOS gene exon7 G894T polymorphism might relate to essential hypertension in Uygur population in Xinjiang province.
