Autoantibodies against beta1 and M2 receptor in diabetic patients with refractory hypertension.
- Author:
Lin-shuang ZHAO
1
;
Yu-hua LIAO
;
Guang-da XIANG
;
Min WANG
;
Zi-hua ZHOU
;
Jie HOU
;
Ling LE
;
Lin XU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Autoantibodies; blood; Diabetes Mellitus, Type 2; blood; complications; Female; Humans; Hypertension; blood; complications; Male; Middle Aged; Receptor, Muscarinic M2; immunology; Receptors, Adrenergic, beta-1; immunology
- From: Chinese Journal of Cardiology 2006;34(5):407-410
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of the autoantibodies against M(2)-muscarinic receptor (M(2)-receptor), beta(1)-adrenergic receptor (beta(1)-receptor) in the development of diabetic with refractory hypertension.
METHODSSerum autoantibodies against M(2) and beta(1) were detected by ELISA using synthesized epitopes of the second extracellular loop of M(2) receptor (169 - 193) and beta(1) receptor (197 - 222) in healthy controls (n = 40), diabetic patients (n = 62), diabetic patients with non-refractory hypertension (n = 55) and diabetic patients with refractory hypertension (n = 81).
RESULTSThe positive rates of the autoantibodies against M(2) receptor and beta(1) receptor were similar among healthy controls (15.0% and 17. 5%), diabetes mellitus patients (17.7% and 14.5%) and diabetic patients with non-refractory hypertension (16.4% and 12.7%) but are significantly higher in diabetic patients with refractory hypertension (64.2% and 55.6%, P < 0.01 vs. other 3 groups).
CONCLUSIONThis finding suggests that autoimmune mechanisms might play a role in the pathogenesis of diabetic patients with refractory hypertension.
