Time distribution of ventricular arrhythmias in patients with Brugada syndrome.
- Author:
Bing YANG
1
;
Ke-jiang CAO
;
Qi-jun SHAN
;
Yun XIA
;
Jing TU
;
Ming-long CHEN
;
Jian-gang ZOU
;
Dong-jie XU
;
Ku-lin LI
;
Chun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Brugada Syndrome; complications; physiopathology; Electrocardiography; Follow-Up Studies; Humans; Male; Middle Aged; Risk Factors; Time; Ventricular Fibrillation; etiology
- From: Chinese Journal of Cardiology 2006;34(5):429-432
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the characterization of time distribution of ventricular arrhythmias in patients with Brugada syndrome (BrS) using Holter monitoring and ICD follow-up.
METHODSPatients with BrS [all male, mean age (41.07 +/- 11.49) years], were divided into ventricular fibrillation (VF) group (n = 7) and no ventricular fibrillation (N-VF) group (n = 7). Premature ventricular capture (PVC) and VF episodes were detected by Holter monitoring and ICD recording.
RESULTSThe 24 hours total number of PVCs ranged from 0 to 74 (mean 9.61 +/- 17.23) in most of the patients and were similar between VF group and N-VF group. The percentage of PVC episodes in VF group was significantly higher than that in N-VF group from nocturnal time to early morning (22:00 to 7:00, 98.67% vs. 44.14%, P < 0.01). There were total 75 VF episodes during (23.18 +/- 17.96) months' follow-up in 5 patients with BrS, 93.3% of which occurred from nocturnal time to early morning (22:00 to 7:00).
CONCLUSIONSThe episodes of PVC were enriched from nocturnal time to early morning in BrS patients, this time distribution could be a new noninvasive risk stratification factor for BrS. The episodes of VF in BrS patients were also enriched from nocturnal time to early morning and this time characteristic of episodes of VF could be used to guide drug therapy.
