Human inward rectifying potassium current in myocytes isolated from patients with rheumatic atrial fibrillation.
- Author:
Biao ZHANG
1
;
Lin TONG
;
Xiao-rong ZENG
;
Yan YANG
;
Zhi-fei LIU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Atrial Fibrillation; metabolism; physiopathology; Female; Humans; Male; Middle Aged; Myocytes, Cardiac; metabolism; Patch-Clamp Techniques; Potassium; metabolism; Potassium Channels, Inwardly Rectifying; metabolism
- From: Chinese Journal of Cardiology 2006;34(5):433-436
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo compare the changes of inward rectifying K(+) (Kir) current (I(K1)) density in atrial myocytes of patients with rheumatic atrial fibrillation (RAF) less or longer than 6 months.
METHODI(K1) density was measured with whole-cell patch clamp technique in single myocyte isolated by an enzymatic dissociation method from right atrial appendages in patients with RAF less than 6 months (n = 18) and longer than 6 months (n = 18), RAF patients with normal sinus rhythm (NSR, n = 18) served as control.
RESULTSThe average resting membrane potentials were similar between various groups. I(K1) density in single myocyte at -50 to -100 mV of patients with RAF longer than 6 months was significantly increased compared to that in patients with RAF less than 6 months and NSR patients. I(K1) density in single myocyte at hyperpolarized potential level (-100 mV) was also significantly increased in patients with RAF longer than 6 months (8.94 +/- 0.15) than that in patients with RAF less than 6 months (4.35 +/- 0.49) and NSR patients compared to that in NSR (4.05 +/- 0.96, P < 0.05 vs RAF longer than 6 months).
CONCLUSIONThe data suggest I(K1) current increase might contribute to the electrical remodeling in RAF patients.
