Expression of TGF-beta1 and the mechanism of invasiveness and metastasis induced by TGF-beta1 in breast cancer.
- Author:
Jian BAO
1
;
Zheng-sheng WU
;
Yue QI
;
Qiang WU
;
Feng YANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Breast Neoplasms; metabolism; pathology; Carcinoma, Ductal, Breast; metabolism; pathology; Female; Follow-Up Studies; Humans; Lymphatic Metastasis; Matrix Metalloproteinase 2; metabolism; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Protein-Serine-Threonine Kinases; metabolism; RNA, Messenger; metabolism; Receptors, Transforming Growth Factor beta; metabolism; Survival Rate; Tissue Inhibitor of Metalloproteinase-1; metabolism; Tissue Inhibitor of Metalloproteinase-2; metabolism; Transforming Growth Factor beta1; genetics; metabolism
- From: Chinese Journal of Oncology 2009;31(9):679-682
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of MMP-2, TIMP-2, TGF-beta1 and TGF-betaRI and the relationship among them in breast cancer.
METHODSThe protein expression of MMP-2, TIMP-2, TGF-beta1 and TGF-betaRI was detected on tissue chips by S-P immunohistochemical staining in 160 cases of breast carcinoma.
RESULTSThe positive rates of TGF-beta1, TGF-beta1 mRNA, MMP-2, MMP-9, TIMP-1 and TIMP-2 expression were 73.7%, 56.2%, 96.9%, 95.0%, 87.5% and 89.4%, respectively. Axillary lymph node metastasis and TNM staging (P < 0.01 and P < 0.01, respectively) were positively correlated to the expression of TGF-beta1. Relase-free survival of TGF-beta1 positive group was lower than that of TGF-beta1 negative group (P = 0.023). The expression of MMP-2 or MMP-9 was positively correlated to that of TGF-beta1 (r = 0.170, P < 0.05; r = 0.221, P < 0.01) and was negatively correlated to that of TGF-beta1 mRNA (r = -0.126, P > 0.05;r = 0.019, P > 0.05).
CONCLUSIONThe expression of TGF-beta1 may be closely correlated with the invasion and metastasis of breast cancer. TGF-beta1-induced invasiveness and metastasis of breast cancer cells are mediated by MMP-2 and MMP-9.
