Association of single nucleotide polymorphism of MnSOD gene with carcinogenesis and development of esophageal squamous cell carcinoma.
- Author:
Yun-jie CHENG
1
;
Ya-di WANG
;
Qing LIU
;
Zhi-ming DONG
;
Feng-peng WU
;
Xiang-ran YANG
;
Xue-ying QIAO
;
Jun ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Carcinoma, Squamous Cell; genetics; pathology; Case-Control Studies; Esophageal Neoplasms; genetics; pathology; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Neoplasm Staging; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Superoxide Dismutase; genetics; Tumor Burden
- From: Chinese Journal of Oncology 2009;31(11):831-835
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of single nucleotide polymorphism (SNP) of manganese superoxide dismutase (MnSOD) gene with carcinogenesis and progression of esophageal squamous cell carcinoma.
METHODSThe MnSOD9 T-->C SNP was genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis in 103 patients with esophageal squamous cell carcinoma and 195 healthy controls.
RESULTSA significant difference was observed in the MnSOD allelotype distribution among esophageal squamous cell carcinomas and healthy controls (chi(2) = 4.645, P < 0.05). Individuals with the 9 C allele had a significantly higher risk to develop esophageal squamous cell carcinoma compared with those with the TT allele. The frequency of C allelotype among patients with lesions of different lengths ( 5 cm) was 16.3% and 36.7%, respectively. A significant difference was observed in the MnSOD allelotype distribution between patients with lesions of different lengths (chi(2) = 5.147, P < 0.05). No significant association of the MnSOD polymorphism at 9 T-->C with the tumor site, maximal length and clinical staging was found in esophageal squamous cell carcinoma.
CONCLUSIONSingle nucleotide polymorphism (SNP) of MnSOD gene may be correlated with the susceptibility and disease progression of esophageal squamous cell carcinoma, and may become a tumor marker for prediction of this cancer.
