Expressions of Ep-CAM and cyclin D1 and their clinical significance in gallbladder carcinoma.
- Author:
Gang REN
1
;
Guo YU
;
Li-wei LIU
;
Lin MA
Author Information
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; pathology; Aged; Antigens, Neoplasm; metabolism; Carcinoma, Adenosquamous; metabolism; pathology; Carcinoma, Squamous Cell; metabolism; pathology; Cell Adhesion Molecules; metabolism; Cell Differentiation; Cyclin D1; metabolism; Epithelial Cell Adhesion Molecule; Female; Gallbladder Neoplasms; metabolism; pathology; Humans; Male; Middle Aged; Neoplasm Staging; Survival Rate
- From: Chinese Journal of Oncology 2009;31(11):841-844
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.
METHODSEp-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 para-cancerous mucosa specimens.
RESULTSEp-CAM and cyclin D1 expressions were detected in 56.7% and 48.3% of the cancer tissues, respectively, significantly higher than those in the normal mucosa (P < 0.05). Ep-CAM expression was not correlated with clinicopathological data, however cyclin D1 expression was correlated with pathological differentiation and necrosis (P < 0.05). Survival analysis showed that patients with positive Ep-CAM or cyclin D1 expression had a shorter survival time than that in the patients without (P < 0.05). Moreover, Ep-CAM and cyclin D1 expressions were positively correlated with each other (r = 0.307, P = 0.017).
CONCLUSIONEp-CAM or cyclin D1 expression is a unfavorable prognostic factor in gallbladder carcinoma.
