Expression of PTEN, matrix metaloproteinases 2 and 9 in thymomas.
- Author:
Zhuang-shi HUANG
1
;
Feng SHI
;
Dong-hong FU
;
Yan-he SU
;
Wan-li LU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Female; Humans; Male; Matrix Metalloproteinase 2; metabolism; Matrix Metalloproteinase 9; metabolism; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; PTEN Phosphohydrolase; metabolism; Paraffin Embedding; Thymoma; metabolism; pathology; Thymus Gland; metabolism; Thymus Neoplasms; metabolism; pathology; Young Adult
- From: Chinese Journal of Oncology 2010;32(1):37-39
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the expression of PTEN, MMP-2 and MMP-9 in thymomas and their correlation with clinical significance.
METHODSImmunohistochemical S-P assay was used to detect the expression of PTEN, MMP-2 and MMP-9 in 45 thymomas and 16 non-neoplastic thymuses.
RESULTSThe positive rate of PTEN, MMP-2 and MMP-9 expression in 45 thymomas were 53.5%, 48.9% and 62.2%, respectively. There were significant differences between non-neoplastic thymus and thymomas (P < 0.05). The expression of PTEN, MMP-2 correlated with histological type (P < 0.05) and different clinical stage of the thymoma (P < 0.01). The expression of MMP-9 was not correlated with histological type and different clinical stages of thymoma (P > 0.05).
CONCLUSIONPTEN, MMP-2 and MMP-9 may play an important role in the occurrence and development of thymoma. The expression of PTEN and MMP-2 correlates with the malignance and the aggression of thymoma.
